Forum: Ernährung - Leere Kalorien und die Ketose

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:-) 6543 Kommentare Angemeldet am: 04.06.2014

01.02.2017

"Bitte mal googeln: "Metformin Krebs" oder "metformin cancer"."

Hab ich und bin noch einen Schritt weiter gegangen (google Suche nach "metformin cancer ncbi") und dann hier gelandet.

"There are however, several unanswered questions regarding the exact mechanism of the anticancer effect of metformin as well as its activity against various types of cancer both in diabetic and nondiabetic populations.

[...]

The current proposed anticancer molecular action of metformin is mainly associated with the inhibition of the mammalian target of rapamycin complex 1 (mTORC1). The mTOR pathway plays a pivotal role in metabolism, growth and proliferation of cancer cell. Metformin is thought to inhibit mTORC1 pathway.

[...]

It is believed that systemic effect of metformin manifested by the reduction of circulating level of insulin and insulin-like growth factor 1 (IGF-1) might be associated with anticancer action. Insulin/IGF-1 is involved not only in regulation of glucose uptake but also in carcinogenesis through upregulation of insulin/IGF receptor signaling pathway. The excessive food consumption (insulin) leads to increased liver production of IGF-1 that binds to IGF-1 receptor and insulin receptor. Then, through insulin receptor substrate (IRS) the signal is transmitted to phosphoinositide 3-kinase (PI3K), and Akt/protein kinase B (PKB) that indirectly activates (not phosphorylates) mTORC1. Additionally, insulin receptor through growth factor receptor-bound protein 2 (GRB2) propagates signal to Ras/Raf/ERK pathway that drives cell growth. Evidences indicate that these pathways play important role in changes of cellular metabolism that are typical feature of tumor cells. Increased levels of circulating insulin/IGF1 and upregulation of insulin/IGF receptor signaling pathways were demonstrated to be involved in the formation of many types of cancer. Metformin was found to reduce insulin level, inhibit insulin/IGF signaling pathways, and modify cellular metabolism in normal and cancer cells."

Der Trick liegt also zum Großteil in einem niedrigen Insulinspiegel. Den gibt es bei KH-Restriktion, offebar bei Metformin-Einahme, aber auch bei guter Insulinsensitvität und bewegungsreichem Lebenswandel (Sport).
Das Problem bei KH-Restriktion ist, dass man (physiologisch) Insulinresistent wird. Sollten dann, warum auch immer, doch mal KHs aufgenommen werden (z.B. Glucosetropf), schießt der Insulinspiegel richtig in die Höhe.

UlliS 402 Kommentare Angemeldet am: 02.08.2003

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02.02.2017

Ich denke, dass das mit der Insulinresistenz weit übertrieben ist. Und zudem: lieber Insulinresistent als tot oder verstümmelt. Die Resistenz lässt sich mit ein bisschen Geduld wieder beseitigen. Das andere nicht.

LG Uli