12.09.2018
Das Thema "Schlaf" scheint beliebt zu sein, dementsprechend zwei weitere Möglichkeiten:
Mariendistelextrakt senkt Cortisol (im Zusammenhang mit Morbus Cushing):
https://www.nature.com/articles/nm.3776
"In Cushing Disease, a brain tumor in the pituitary gland causes the secretion of increased levels of the stress hormone adrenocorticotropin (ACTH), which triggers the release of the stress hormone cortisol from the adrenal glands — which leads to fat gain, muscular weakness, elevated blood pressure, and diminished testosterone levels, amongst other things.
Patients with the disease are highly prone to microbial infections, depression, osteoporosis, and may show cognitive deficiencies. Standard treatment for severe case currently is brain surgery — which in 80-85% of cases results in the tumor being removed. Inoperable cases exist though — and as it stands are treated with a regimen that is accompanied by severe side effects.
Effective treatment via simpler, cheaper, and safer, compounds such as silbinin (milk thistle extract) would be of great use.
“Silibinin is the major active constituent of milk thistle seeds. It has an outstanding safety profile in humans and is already used for the treatment of liver disease and poisoning,” stated Marcelo Paez-Pereda, lead researcher behind the new study. (See: Milk Thistle (Silybum marianum) Benefits, Side Effects, & Silymarin Uses + Research Findings)
The research found that with silibinin treatment, tumour cells reverted to normal ACTH production, tumor growth slowed down considerably, and “symptoms of Cushing Disease disappeared in mice”."
Die Aminosäure Glycin (v.a. vorhanden in kollagenem Eiweiß, 3 g vor dem Schlafen) verbessert subjektiv die Schlafqualität:
https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1479-8425.2007.00262.x
"In human volunteers who have been continuously experiencing unsatisfactory sleep, effects of glycine ingestion (3 g) before bedtime on subjective sleep quality were investigated, and changes in polysomnography (PSG) during sleep were analyzed. Effects on daytime sleepiness and daytime cognitive function were also evaluated. Glycine improved subjective sleep quality and sleep efficacy (sleep time/in‐bed time), and shortened PSG latency both to sleep onset and to slow wave sleep without changes in the sleep architecture. Glycine lessened daytime sleepiness and improved performance of memory recognition tasks. Thus, a bolus ingestion of glycine before bedtime seems to produce subjective and objective improvement of the sleep quality in a different way than traditional hypnotic drugs such as benzodiazepines."
